Friday, September 30, 2016

Citation bias favoring positive clinical trials

Positive trials of tPA for ischemic stroke are cited more often than neutral trials or negative trials. Trials. 2016;17(1):473

Comment: This study found that there is a significant amount of CITATION BIAS in the use of tPA in ischemic stroke. Perhaps this is because we always want to do something, like give a fancy drug or call a Code Stroke, rather than just stand by and give aspirin or clopidogrel. This citation bias may have disasterous results, so must be strongly guarded against.